2-Chloro-5-(4-[1,2,3]triazol-1-yl-but-1-ynyl)-pyrimidine → 2-Chloro-5-(4-[1,2,3]triazol-1-yl-butyl)-pyrimidine

HRID 349233ノート

反応式

HRID 349233 の反応式
[Cl:1][C:2]1[N:7]=[CH:6][C:5]([C:8]#[C:9][CH2:10][CH2:11][N:12]2[CH:16]=[CH:15][N:14]=[N:13]2)=[CH:4][N:3]=1>C(OCC)(=O)C.[Pd]>[Cl:1][C:2]1[N:7]=[CH:6][C:5]([CH2:8][CH2:9][CH2:10][CH2:11][N:12]2[CH:16]=[CH:15][N:14]=[N:13]2)=[CH:4][N:3]=1

参加物

4

反応物 1

HCID 860740652-Chloro-5-(4-[1,2,3]triazol-1-yl-but-1-ynyl)-pyrimidine

生成物 1

HCID 860740662-Chloro-5-(4-[1,2,3]triazol-1-yl-butyl)-pyrimidine

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 8857Ethyl Acetate溶媒

実験手順

2-Chloro-5-(4-[1,2,3]triazol-1-yl-but-1-ynyl)-pyrimidine (2.52 g, 10.8 mmol) is dissolved in ethyl acetate (210 ml) and hydrogenated for 2.5 h at r.t. in the presence of palladium on calcium carbonate (10%, 2.55 g). The reaction mixture is filtered and concentrated in vacuo to yield 2-chloro-5-(4-[1,2,3]triazol-1-yl-butyl)-pyrimidine as a colorless solid. Yield 2.15 g (84%)

後処理

  1. filtrationThe reaction mixture is filtered
  2. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-e8d62ce74d1a4fe5b00240188bfcef13
出典データセット
uspto-grants-2007_02
特許番号
US07179812B2

反応ノート

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