Hydrochloric Acid → N-(2-aminoethyl)-3-phenoxypyridine-2-carboxamide hydrochloride
反応式
[O:1]([C:8]1[C:9]([C:14]([NH:16][CH2:17][CH2:18][NH:19]C(=O)OC(C)(C)C)=[O:15])=[N:10][CH:11]=[CH:12][CH:13]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.FC(F)(F)C(O)=O.[ClH:34]>>[ClH:34].[NH2:19][CH2:18][CH2:17][NH:16][C:14]([C:9]1[C:8]([O:1][C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=2)=[CH:13][CH:12]=[CH:11][N:10]=1)=[O:15]参加物
4
実験手順
8.7 g of t-butyl [2-(3-phenoxypyridine-2-carboxamido)ethyl]carbamate were reacted with trifluoroacetic acid in an analogous manner to that described in Example 3, paragraph 2. The residue was converted into the hydrochloride which was recrystallized twice from ethanol/ether, whereby there was obtained N-(2-aminoethyl)-3-phenoxypyridine-2-carboxamide hydrochloride as white crystals, m.p. 180°-186°.
後処理
- customwas recrystallized twice from ethanol/ether
出典と根拠
- ORDレコード
- ord-64f995007abf4ea6972aba508349a44e
- 出典データセット
- uspto-grants-1988_08
- 特許番号
- US04764522
反応ノート
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