Chloroform → Methyl 3-acetamido-4,5-dichlorothiophene-2-carboxylate

HRID 349428ノート

反応式

HRID 349428 の反応式
[C:1]([NH:4][C:5]1[CH:9]=C[S:7][C:6]=1[C:10]([O:12][CH3:13])=[O:11])(=[O:3])[CH3:2].S(Cl)([Cl:17])(=O)=O.[CH:19]([Cl:22])(Cl)Cl>>[C:1]([NH:4][C:5]1[C:9]([Cl:17])=[C:19]([Cl:22])[S:7][C:6]=1[C:10]([O:12][CH3:13])=[O:11])(=[O:3])[CH3:2]

参加物

4

反応物 3

HCID 6212Chloroform2 回HCID 24648Sulfuryl chlorideHCID 729216methyl 3-acetamidothiophene-2-carboxylate

生成物 1

HCID 22139803Methyl 3-acetamido-4,5-dichlorothiophene-2-carboxylate

反応条件

温度
40 °C

実験手順

was obtained by reacting 19.9 g of methyl 3-acetylaminothiophene-2-carboxylate in 100 ml of chloroform with 17.9 ml of sulfuryl chloride (SO2Cl2) in 120 ml of chloroform by stirring at 40° C. for 2 hours and subsequently boiling under reflux conditions for 15 minutes. After the solvent had been distilled off, the residue was crystallized in ethyl acetate.

後処理

  1. customwas obtained
  2. waitsubsequently boiling under reflux conditions for 15 minutes
  3. distillationAfter the solvent had been distilled off
  4. customthe residue was crystallized in ethyl acetate

出典と根拠

ORDレコード
ord-1be62623a17a47cabd5b61e31375bf48
出典データセット
uspto-grants-2007_02
特許番号
US07179830B2

反応ノート

読み込み中…