8alpha-Benzyloxycarbonylamino-6-n-propylergoline → 8alpha-Amino-6-n-propylergoline

HRID 34957ノート

反応式

HRID 34957 の反応式
C(OC([NH:11][C@H:12]1[CH2:26][C@H:25]2[C@@H:15]([CH2:16][C:17]3[C:27]4[C:20](=[CH:21][CH:22]=[CH:23][C:24]2=4)[NH:19][CH:18]=3)[N:14]([CH2:28][CH2:29][CH3:30])[CH2:13]1)=O)C1C=CC=CC=1.[H][H]>[Pd].C(O)C>[NH2:11][C@H:12]1[CH2:26][C@H:25]2[C@@H:15]([CH2:16][C:17]3[C:27]4[C:20](=[CH:21][CH:22]=[CH:23][C:24]2=4)[NH:19][CH:18]=3)[N:14]([CH2:28][CH2:29][CH3:30])[CH2:13]1

参加物

5

反応物 2

HCID 139664588alpha-Benzyloxycarbonylamino-6-n-propylergolineHCID 178418361HCID 178418361、化合物

生成物 1

HCID 134688038alpha-Amino-6-n-propylergoline

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

12 g (ca 30 mM) of 8α-benzyloxycarbonylamino)-6-n-propylergoline obtained from step (d) and 1.5 g palladium on charcoal (10% by weight) in 500 ml ethanol are hydrogenated at normal pressure until hydrogen uptake ceases. The mixture is filtered and concentrated. This resultant heading compound is crystallised from methanol.

後処理

  1. filtrationThe mixture is filtered
  2. concentrationconcentrated
  3. customis crystallised from methanol

出典と根拠

ORDレコード
ord-1847d07e81a74fdd8f8adb629f105173
出典データセット
uspto-grants-1988_08
特許番号
US04764517

反応ノート

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