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Acetic Anhydride → N-(5-Acetyl-indan-2-YL)-4-fluoro-benzamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Acetic Anhydride | HCID 7918 | — |
| 反応物 | Aluminum(III) Chloride | HCID 6451240 | — |
| 反応物 | Ave-9488 | HCID 10131276 | — |
| 溶媒 | 1,2-Dichloroethane | HCID 11 | — |
| 生成物 | N-(5-Acetyl-indan-2-YL)-4-fluoro-benzamide | HCID 21920974 | — |
反応手順
2.87 g (21.6 mmol) aluminum trichloride were suspended in 10 ml 1,2-dichloroethane, 500 mg (4.9 mmol) acetic anhydride and 1.0 g N-(indan-2-yl)-4-fluoro-benzamide added, and the whole was stirred for 2 h at RT. The resulting mixture was poured onto ice water/HCl, extracted with dichloromethane, the organic phase was dried with Na2SO4 and evaporated.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07179839B2 |
| 出典データセット | uspto-grants-2007_02 |
| ORD ID | ord-12d8dcb51e2c4376b2cab1e7072141cf |
| 出典メモ | uspto-grants-2007_02 |