5-Morpholino-2-nitroaniline → 4-(Morpholin-4-yl)benzene-1,2-diamine
反応式
[N:1]1([C:7]2[CH:8]=[CH:9][C:10]([N+:14]([O-])=O)=[C:11]([NH2:13])[CH:12]=2)[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.[H][H]>C(O)(=O)C.C(O)C.[Pd]>[N:1]1([C:7]2[CH:12]=[C:11]([NH2:13])[C:10]([NH2:14])=[CH:9][CH:8]=2)[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1参加物
6
実験手順
A solution of 5-morpholin-4-yl-2-nitro-phenylamine (4.0 g, 0.02 mol) in acetic acid (100 mL) and ethanol (100 mL) was treated with hydrogen gas (60 psi) for 30 min in the presence of palladium on carbon catalyst (0.5 g, 10% Pd). The catalyst was removed by filtration through CELITE®, and the filtrate was concentrated to a syrup and dried in vacuo to afford the intermediate 4-morpholin-4-yl-benzene-1,2-diamine as a crude green solid (3.2 g).
後処理
- customThe catalyst was removed by filtration through CELITE®
- concentrationthe filtrate was concentrated to a syrup
- customdried in vacuo
出典と根拠
- ORDレコード
- ord-ac74ca14d2064a72aa4797f9e7d3f434
- 出典データセット
- uspto-grants-2007_02
- 特許番号
- US07179912B2
反応ノート
読み込み中…