Oxalyl chloride → 2-Chloro-4,5-difluorobenzoyl Isocyanate

HRID 349728ノート

反応式

HRID 349728 の反応式
[Cl:1][C:2]1[CH:10]=[C:9]([F:11])[C:8]([F:12])=[CH:7][C:3]=1[C:4]([NH2:6])=[O:5].C(Cl)(=O)[C:14](Cl)=[O:15]>ClCCl>[Cl:1][C:2]1[CH:10]=[C:9]([F:11])[C:8]([F:12])=[CH:7][C:3]=1[C:4]([N:6]=[C:14]=[O:15])=[O:5]

参加物

4

反応物 2

HCID 65578Oxalyl chlorideHCID 23171512-Chloro-4,5-difluorobenzamide

生成物 1

HCID 115575832-Chloro-4,5-difluorobenzoyl Isocyanate

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

2-Chloro-4,5-difluorobenzamide was dissolved in dichloromethane, admixed with 1.5 eq. of oxalyl chloride and heated to reflux for 16 hours. The reaction mixture was concentrated under high vacuum and reacted in stage b without further purification.

後処理

  1. temperatureheated
  2. temperatureto reflux for 16 hours
  3. concentrationThe reaction mixture was concentrated under high vacuum
  4. customreacted in stage b without further purification

出典と根拠

ORDレコード
ord-37b2489659b54d3c86a3d1c2a4eced91
出典データセット
uspto-grants-2007_02
特許番号
US07179941B2

反応ノート

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