Phenol → 6-(2-Pentyl-3,4-dichlorophenoxy)hexanoic acid

HRID 34974

反応式

HRID 34974 の反応式
[OH:1][CH:2]1[CH2:6][C:5]2C(Cl)=C(Cl)[CH:9]=[CH:10][C:4]=2[O:3]1.[Br-].C([P+](C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1)CC.[CH2:36]([C:41]1[C:46]([Cl:47])=[C:45]([Cl:48])[CH:44]=[CH:43][C:42]=1[OH:49])[CH:37]=[CH:38][CH2:39][CH3:40].C(C1C(Cl)=C(Cl)C=CC=1O)CCCC.C1(O)C=CC=CC=1.BrCCCCCC(O)=O>>[CH2:36]([C:41]1[C:46]([Cl:47])=[C:45]([Cl:48])[CH:44]=[CH:43][C:42]=1[O:49][CH2:9][CH2:10][CH2:4][CH2:5][CH2:6][C:2]([OH:3])=[O:1])[CH2:37][CH2:38][CH2:39][CH3:40]

参加物

7

反応物 6

HCID 996PhenolHCID 202106-Bromohexanoic acidHCID 80374Propyltriphenylphosphonium bromideHCID 212972802-Pentyl-3,4-dichlorophenolHCID 212972952,3-Dihydro-2-hydroxy-4,5-dichlorobenzofuranHCID 544116102-(2-Pentenyl)-3,4-dichlorophenol

生成物 1

HCID 212973066-(2-Pentyl-3,4-dichlorophenoxy)hexanoic acid

実験手順

Following the general procedure of Example 6B, 2.3 g. of 2,3-dihydro-2-hydroxy-4,5-dichlorobenzofuran and 17.3 g. of propyltriphenylphosphonium bromide were reacted to provide 840 mg. of 2-(2-pentenyl)-3,4-dichlorophenol which upon hydrogenation following the procedure of Example 6C provided 300 mg. of 2-pentyl-3,4-dichlorophenol. This phenol was then reacted with 5.1 mmoles of 6-bromohexanoic acid following the procedure of Example 1C to provide 58 mg. of the desired title product. NMR.

後処理

  1. customto provide 840 mg
  2. customprovided 300 mg
  3. customto provide 58 mg

出典と根拠

ORDレコード
ord-bcfad02dc81843998440c27ff8dbbb80
出典データセット
uspto-grants-1988_08
特許番号
US04764521

関連ノート

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