化工社化工社 化学情報印刷レポート · 研究参考用
Water → Codeine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | Morphine | HCID 5288826 | — |
| 触媒 | Phenyltrimethylammonium chloride | HCID 67309 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | Codeine | HCID 5284371 | 95.6% |
反応手順
Morphine of 89.0% purity 320 parts (1 mole part), potassium carbonate 552 parts (4 moles part), water 65 parts and trimethylphenylammonium chloride 188 parts (1.1 moles part) are heated under stirring in toluene (4000 parts) at 45° to 120° C. for 2 to 8 hrs. to yield 296 parts codeine (95.6% yield after workup as in Example 1.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04764615 |
| 出典データセット | uspto-grants-1988_08 |
| ORD ID | ord-de6aa70261ab4783b10797d3fce05e0e |
| 出典メモ | uspto-grants-1988_08 |