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HRID34988

反应详情

EQUATION

反应方程式

HRID 34988 的结构方程式

REACTANTS

反应物

3
结构：O
HCID962

Water

H2O

结构：O=C([O-])[O-].[K+].[K+]
HCID11430

Potassium Carbonate

CK2O3

结构：CN1CC[C@]23c4c5ccc(O)c4O[C@H]2[C@@H](O)C=C[C@H]3[C@H]1C5
HCID5288826

Morphine

C17H19NO3

PRODUCTS

生成物

1
结构：COc1ccc2c3c1O[C@H]1[C@@H](O)C=C[C@H]4[C@@H](C2)N(C)CC[C@@]341
HCID5284371

Codeine

C18H21NO3

收率 95.6%

AUXILIARIES

试剂、催化剂与溶剂

2
结构：C[N+](C)(C)c1ccccc1.[Cl-]
催化剂HCID67309

未命名化合物

结构：Cc1ccccc1
溶剂HCID1140

Toluene

C7H8

PROCEDURE

实验过程

Morphine of 89.0% purity 320 parts (1 mole part), potassium carbonate 552 parts (4 moles part), water 65 parts and trimethylphenylammonium chloride 188 parts (1.1 moles part) are heated under stirring in toluene (4000 parts) at 45° to 120° C. for 2 to 8 hrs. to yield 296 parts codeine (95.6% yield after workup as in Example 1.