Tetrahydrofuran → HCID 178470731、化合物

HRID 350017ノート

反応式

HRID 350017 の反応式
[CH2:1]([N:8]1[CH:12]=[C:11]([CH2:13][C:14]([O:16][CH2:17][CH3:18])=[O:15])[C:10]([O:19]CC2C=CC=CC=2)=[N:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.O1CCCC1>[C].[Pd].C(O)C>[CH2:1]([N:8]1[CH:12]=[C:11]([CH2:13][C:14]([O:16][CH2:17][CH3:18])=[O:15])[C:10]([OH:19])=[N:9]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

参加物

5

反応物 2

HCID 8028TetrahydrofuranHCID 69422631ethyl 1-benzyl-3-benzyloxy-1H-pyrazol-4-ylacetate

生成物 1

HCID 178470731HCID 178470731、化合物収率 88.2%

試薬・触媒・溶媒 2

HCID 178418390HCID 178418390、化合物触媒HCID 702Ethanol溶媒

実験手順

A mixture of ethyl 1-benzyl-3-benzyloxy-1H-pyrazol-4-ylacetate (14.9 g), 5% palladium-carbon (15.0 g), tetrahydrofuran (150 ml) and ethanol (150 ml) was stirred for 2 hours under a hydrogen atmosphere. After the palladium-carbon was removed by filtration, the filtrate was concentrated to obtain ethyl 1-benzyl-3-hydroxy-1H-pyrazol-4-ylacetate (9.76 g, yield 88%) as colorless crystals. This was recrystallized from tetrahydrofuran-hexane. Melting point: 156–157° C.

後処理

  1. customAfter the palladium-carbon was removed by filtration
  2. concentrationthe filtrate was concentrated

出典と根拠

ORDレコード
ord-54ab987a499c47b6843be222443855df
出典データセット
uspto-grants-2007_02
特許番号
US07179823B1

反応ノート

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