Chlorosuccinimide → N-[4-(3-Chloro-5H-pyrrolo[2,1-c][1,4]benzodiazepin-10(11H)ylcarbonyl)phenyl]-2-methylbenzamide

HRID 3501

反応式

HRID 3501 の反応式
[CH3:1][C:2]1[CH:32]=[CH:31][CH:30]=[CH:29][C:3]=1[C:4]([NH:6][C:7]1[CH:12]=[CH:11][C:10]([C:13]([N:15]2[C:21]3[CH:22]=[CH:23][CH:24]=[CH:25][C:20]=3[CH2:19][N:18]3[CH:26]=[CH:27][CH:28]=[C:17]3[CH2:16]2)=[O:14])=[CH:9][CH:8]=1)=[O:5].[Cl:33]N1C(=O)CCC1=O>O1CCCC1>[Cl:33][C:26]1[N:18]2[C:17]([CH2:16][N:15]([C:13]([C:10]3[CH:9]=[CH:8][C:7]([NH:6][C:4](=[O:5])[C:3]4[CH:29]=[CH:30][CH:31]=[CH:32][C:2]=4[CH3:1])=[CH:12][CH:11]=3)=[O:14])[C:21]3[CH:22]=[CH:23][CH:24]=[CH:25][C:20]=3[CH2:19]2)=[CH:28][CH:27]=1

参加物

4

反応物 2

HCID 31398ChlorosuccinimideHCID 107646642-Methyl-N-[4-(5H-pyrrolo[2,1-c][1,4]-benzodiazepin-10(11H)-ylcarbonyl)phenyl]benzamide

生成物 1

HCID 21836983N-[4-(3-Chloro-5H-pyrrolo[2,1-c][1,4]benzodiazepin-10(11H)ylcarbonyl)phenyl]-2-methylbenzamide収率 68.8%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

To an ice-water cooled suspension of 211 mg of 2-methyl-N-[4-(5H-pyrrolo[2,1-c][1,4]-benzodiazepin-10(11H)-ylcarbonyl)-phenyl]benzamide in 5 ml of tetrahydrofuran is added 67 mg of N-chlorosuccinimide followed by continued stirring in the cold for 10 minutes. The bath is removed and stirring continued for 2.25 hours. The reaction mixture is added to ice-water and extracted with ether. The organic layer is dried and concentrated in vacuo to give a foam which is crystallized from ethyl acetate-hexane to give 157 mg of the desired product as an orange-pink solid, m.p. 185°-187° C.

後処理

  1. customThe bath is removed
  2. stirringstirring
  3. waitcontinued for 2.25 hours
  4. additionThe reaction mixture is added to ice-water
  5. extractionextracted with ether
  6. customThe organic layer is dried
  7. concentrationconcentrated in vacuo
  8. customto give a foam which
  9. customis crystallized from ethyl acetate-hexane

出典と根拠

ORDレコード
ord-541e4ed91a3e4fd299ddfcb9db583d18
出典データセット
uspto-grants-1998_03
特許番号
US05733905

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