Hydrochloric Acid → HCID 13799565、化合物

HRID 35028ノート

反応式

HRID 35028 の反応式
[CH2:1]([S:8][C:9]1[N:10]([C:19]2[C:24]([CH2:25][CH3:26])=[CH:23][CH:22]=[CH:21][C:20]=2[CH2:27][CH3:28])[C:11]([C:14]([O:16]CC)=[O:15])=[CH:12][N:13]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH-].[Na+].Cl>>[CH2:1]([S:8][C:9]1[N:10]([C:19]2[C:24]([CH2:25][CH3:26])=[CH:23][CH:22]=[CH:21][C:20]=2[CH2:27][CH3:28])[C:11]([C:14]([OH:16])=[O:15])=[CH:12][N:13]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

4

反応物 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 13799562Ethyl 2-benzylthio-1-(2,6-diethylphenyl)-imidazole-5-carboxylate

生成物 1

HCID 13799565HCID 13799565、化合物収率 90%

実験手順

31.5 g (0.08 mol) of ethyl 2-benzylthio-1-(2,6-diethylphenyl)-imidazole-5-carboxylate (cf. Example 2) were stirred with 30 g of 33% strength sodium hydroxide solution at 80° C. until a homogeneous solution was formed. The solution was allowed to cool and acidified to pH 3 with dilute hydrochloric acid, and the product was filtered off under suction and dried in vacuo. 26.4 g (90% of theory) of 2-benzylthio-1-(2,6-diethylphenyl)-imidazole-5-carboxylic acid, solid at melting point 152°-154° C., were obtained.

後処理

  1. customwas formed
  2. temperatureto cool
  3. filtrationthe product was filtered off under suction
  4. customdried in vacuo

出典と根拠

ORDレコード
ord-7c7d012f18ff4d62afa11b93fade8e5c
出典データセット
uspto-grants-1988_08
特許番号
US04764624

反応ノート

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