Ammonia → HCID 178436224、化合物

HRID 35029ノート

反応式

HRID 35029 の反応式
[Na].C([S:9][C:10]1[N:11]([C:18]2[C:23]([CH2:24][CH3:25])=[CH:22][CH:21]=[CH:20][C:19]=2[CH2:26][CH3:27])[C:12]([C:15]([OH:17])=[O:16])=[CH:13][N:14]=1)C1C=CC=CC=1.N.[Cl-].[NH4+].Cl>O>[CH2:26]([C:19]1[CH:20]=[CH:21][CH:22]=[C:23]([CH2:24][CH3:25])[C:18]=1[N:11]1[C:12]([C:15]([OH:17])=[O:16])=[CH:13][N:14]=[C:10]1[SH:9])[CH3:27]

参加物

7

反応物 5

HCID 222AmmoniaHCID 313Hydrochloric AcidHCID 25517Ammonium ChlorideHCID 5360545SodiumHCID 13799565HCID 13799565、化合物

生成物 1

HCID 178436224HCID 178436224、化合物

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

2.3 g (0.1 mol) of sodium were added in portions to a suspension of 5 g (0.014 mol) of 2-benzylthio-1-(2,6-diethylphenyl)-imidazole-5-carboxylic acid in 50 ml of liquid ammonia at -40° to -50° C. After 1 hour, 6 g of ammonium chloride were added at the same temperature, and the mixture was allowed to warm up to room temperature overnight. The residue was taken up in 200 ml of water, and the solution was acidified to pH 3 with semiconcentrated hydrochloric acid and filtered under suction. 3.0 g (79% of theory) of 1-(2,6-diethylphenyl)-2-mercaptoimidazole-5-carboxylic acid, a solid having a melting point above 230° C., were obtained.

後処理

  1. filtrationfiltered under suction
  2. customwere obtained

出典と根拠

ORDレコード
ord-b8679006a4264c0387f20959b5088f79
出典データセット
uspto-grants-1988_08
特許番号
US04764624

反応ノート

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