Piperidine → Methyl 3-(piperidin-1-ylmethyl)benzoate
反応式
[NH:1]1[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.Br[CH2:8][C:9]1[CH:10]=[C:11]([CH:16]=[CH:17][CH:18]=1)[C:12]([O:14][CH3:15])=[O:13]>C1(C)C=CC=CC=1>[N:1]1([CH2:8][C:9]2[CH:10]=[C:11]([CH:16]=[CH:17][CH:18]=2)[C:12]([O:14][CH3:15])=[O:13])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1参加物
4
実験手順
A mixture of piperidine (25 ml) and 3-(bromomethyl)benzoic acid, methyl ester (20 g) in toluene (600 ml) was stirred at room temperature for 4 h. The white preciptiate was removed by filtration and the filtrate was distilled to give the title compound as a colourless oil (17.56 g) b.p. 110° (10-1 mm). TLC silica; ether; Rf 0.7.
後処理
- customThe white preciptiate was removed by filtration
- distillationthe filtrate was distilled
出典と根拠
- ORDレコード
- ord-d2db7d61cdb94d9a851edbff15c6518d
- 出典データセット
- uspto-grants-1988_08
- 特許番号
- US04764612
反応ノート
読み込み中…