Hydrochloric Acid → HCID 178520398、化合物

HRID 350616

反応式

HRID 350616 の反応式
[C:1]([CH2:3][C:4]([NH:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)=[O:5])#[N:2].C([Sn]([N:26]=[N+:27]=[N-:28])(CCCC)CCCC)CCC.Cl>C1(C)C=CC=CC=1.CCOCC>[NH:26]1[C:1]([CH2:3][C:4]([NH:6][C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)=[O:5])=[N:2][N:28]=[N:27]1

参加物

6

反応物 3

HCID 313Hydrochloric AcidHCID 69296Acetamide, 2-cyano-N-phenyl-HCID 4984872Tributyltin azide

生成物 1

HCID 178520398HCID 178520398、化合物収率 90.3%

試薬・触媒・溶媒 2

HCID 1140Toluene溶媒HCID 3283Diethyl Ether溶媒

実験手順

A solution of 2-cyano-acetanilide (0.801 g, 5.0 mmol) and tri-n-butyltin azide (2.05 mL, 7.5 mmol) in anhydrous toluene (10 mL) was heated at reflux for 48 hrs. The mixture was allowed to cool to room temperature and treated with 2.0 N HCl in Et2O (5.0 mL). The resulting precipate was collected by suction, washed with hexane and dried in vacuo to give 2-(1H-tetrazol-5-yl)acetanilide (0.917 g, 90%) as a white solid.

後処理

  1. temperatureat reflux for 48 hrs
  2. customThe resulting precipate was collected by suction
  3. washwashed with hexane
  4. customdried in vacuo

出典と根拠

ORDレコード
ord-c70a5eba16b7425b8003797554719346
出典データセット
uspto-grants-2007_02
特許番号
US07183260B2

関連ノート

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