Imidazole → HCID 23061751、化合物

HRID 350730

反応式

HRID 350730 の反応式
Cl[C:2]1[O:3][C:4]([CH2:14][CH2:15][C:16]([O:18][CH3:19])=[O:17])=[C:5]([C:7]2[CH:12]=[CH:11][C:10]([Cl:13])=[CH:9][CH:8]=2)[N:6]=1.[NH:20]1[CH:24]=[CH:23][N:22]=[CH:21]1.CN(C)C=O.[H-].[Na+]>O>[Cl:13][C:10]1[CH:11]=[CH:12][C:7]([C:5]2[N:6]=[C:2]([N:20]3[CH:24]=[CH:23][N:22]=[CH:21]3)[O:3][C:4]=2[CH2:14][CH2:15][C:16]([O:18][CH3:19])=[O:17])=[CH:8][CH:9]=1

参加物

6

反応物 4

HCID 795ImidazoleHCID 6228DimethylformamideHCID 24758Sodium hydrideHCID 10990225Methyl 3-[2-chloro-4-(4-chlorophenyl)-5-oxazolyl]propionate

生成物 1

HCID 23061751HCID 23061751、化合物収率 80%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

To a mixed solution of methyl 3-[2-chloro-4-(4-chlorophenyl)-5-oxazolyl]propionate (3.0 g), imidazole (0.82 g) and N,N-dimethylformamide (20 mL) was added sodium hydride (60% in oil, 0.5 g), and the mixture was stirred at room temperature for 1 hr. The reaction mixture was poured into iced water, and the precipitated crystals were collected by filtration to give methyl 3-[4-(4-chlorophenyl)-2-(1H-imidazol-1-yl)-5-oxazolyl]propionate (1.6 g, yield 80%) as crystals. Recrystallization from methanol gave colorless prism crystals. melting point: 95–96° C.

後処理

  1. filtrationthe precipitated crystals were collected by filtration

出典と根拠

ORDレコード
ord-6fe51e38a08f436da752093e9c711637
出典データセット
uspto-grants-2007_02
特許番号
US07183276B2

関連ノート

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