Sodium Hydroxide → 3-(3-Phenylsulfamoylphenyl)acrylic acid

HRID 351030ノート

反応式

HRID 351030 の反応式
C[O:2][C:3](=[O:22])[CH:4]=[CH:5][C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([S:12](=[O:21])(=[O:20])[NH:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH:7]=1.[OH-].[Na+]>CO>[C:14]1([NH:13][S:12]([C:8]2[CH:7]=[C:6]([CH:5]=[CH:4][C:3]([OH:22])=[O:2])[CH:11]=[CH:10][CH:9]=2)(=[O:21])=[O:20])[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=1

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 67019508Methyl 3-[3-(phenylsulfamoyl)phenyl]prop-2-enoate

生成物 1

HCID 670195203-(3-Phenylsulfamoylphenyl)acrylic acid収率 82.7%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

3-(3-Phenylsulfamoylphenyl)acrylic acid methyl ester (4a) (0.220 g, 0.69 mmol) was dissolved in methanol (3 ml), 1N NaOH (2.08 ml, 2.08 mmol) was added and the resultant solution was stirred at ambient temperature overnight. The reaction mixture was partitioned between ethyl acetate and water. The aqueous layer was acidified with 10% HCl and stirred for 30 min. The precipitated solid was filtered, washed with water and dried in desiccator over P2O5 to give the title compound as a white solid (0.173 g, 82%).

後処理

  1. customThe reaction mixture was partitioned between ethyl acetate and water
  2. filtrationThe precipitated solid was filtered
  3. washwashed with water
  4. dry with materialdried in desiccator over P2O5

出典と根拠

ORDレコード
ord-042e572164214f4ea9bb08c242c4536f
出典データセット
uspto-grants-2007_02
特許番号
US07183298B2

反応ノート

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