Diethyl Ether → HCID 10084623、化合物

HRID 351110ノート

反応式

HRID 351110 の反応式
[C:1](Cl)(=[O:3])[CH3:2].[NH2:5][C:6]1[S:10][C:9]2[C:11]3[C:16]([CH2:17][C:8]=2[C:7]=1[C:18]([NH2:20])=[O:19])=[CH:15][CH:14]=[CH:13][CH:12]=3.C(OCC)C>N1C=CC=CC=1>[C:1]([NH:5][C:6]1[S:10][C:9]2[C:11]3[C:16]([CH2:17][C:8]=2[C:7]=1[C:18]([NH2:20])=[O:19])=[CH:15][CH:14]=[CH:13][CH:12]=3)(=[O:3])[CH3:2]

参加物

5

反応物 3

HCID 3283Diethyl EtherHCID 6367Acetyl chlorideHCID 10220223HCID 10220223、化合物

生成物 1

HCID 10084623HCID 10084623、化合物収率 87%

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

実験手順

Acetyl chloride (0.039 g, 0.5 mmol) was added dropwise to a stirred solution of 2-amino-4H-indeno[1,2-b]thiophene-3-carboxylic acid amide(0.115 g, 0.5 mmol) in dry pyridine (3 mL) at room temperature. The resulting reaction mixture was stirred under nitrogen for 2 h. Ethyl ether (20 mL) was then added to the reaction mixture. The reaction mixture was allowed to stir an additional 10 minutes. The reaction mixture was then filtered, washed with excess ethyl ether, air dried to give the title compound as light brown solid (0.082 g, 0.435 mmol, 60.3% yield). ESMS m/z: 273 [M+H]+.

後処理

  1. customThe resulting reaction mixture
  2. stirringto stir an additional 10 minutes
  3. filtrationThe reaction mixture was then filtered
  4. washwashed with excess ethyl ether, air
  5. customdried

出典と根拠

ORDレコード
ord-73fe2dbbfcfe48d5b116748357374bf3
出典データセット
uspto-grants-2007_02
特許番号
US07183311B2

反応ノート

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