4-tert-Butylcyclohexylamine → N-(4-tert-Butylcyclohexyl)-N'-(7-hydroxynaphthalen-1-yl)urea

HRID 351286

反応式

HRID 351286 の反応式
[C:1]([CH:5]1[CH2:10][CH2:9][CH:8]([NH2:11])[CH2:7][CH2:6]1)([CH3:4])([CH3:3])[CH3:2].C1([O:18][C:19](=O)[NH:20][C:21]2[C:30]3[C:25](=[CH:26][CH:27]=[C:28]([OH:31])[CH:29]=3)[CH:24]=[CH:23][CH:22]=2)C=CC=CC=1>CS(C)=O>[C:1]([CH:5]1[CH2:6][CH2:7][CH:8]([NH:11][C:19]([NH:20][C:21]2[C:30]3[C:25](=[CH:26][CH:27]=[C:28]([OH:31])[CH:29]=3)[CH:24]=[CH:23][CH:22]=2)=[O:18])[CH2:9][CH2:10]1)([CH3:4])([CH3:2])[CH3:3]

参加物

4

反応物 2

HCID 793964-tert-ButylcyclohexylamineHCID 20090380(7-Hydroxy-naphthalen-1-yl)-carbamic acid phenyl ester

生成物 1

HCID 18435880N-(4-tert-Butylcyclohexyl)-N'-(7-hydroxynaphthalen-1-yl)urea

試薬・触媒・溶媒 1

HCID 679Dimethyl Sulfoxide溶媒

実験手順

4-tert-Butyl-cyclohexylamine (69 mg, 0.44 mmol) and (7-hydroxy-naphthalen-1-yl)-carbamic acid phenyl ester (125 mg, 0.44 mmol) were combined and stirred at ambient temperature in DMSO (3 mL) overnight. The product was purified by directly injecting the crude reaction onto a reverse phase prep-HPLC (90–10% water:acetonitrile gradient). The appropriate fractions were lyophilized to yield 1-(4-tert-Butyl-cyclohexyl)-3-(7-hydroxy-naphthalen-1-yl)-urea

後処理

  1. customThe product was purified
  2. customreaction onto a reverse phase prep-HPLC (90–10% water:acetonitrile gradient)

出典と根拠

ORDレコード
ord-75db14825a1f48a6961e36069b97b72c
出典データセット
uspto-grants-2007_02
特許番号
US07183411B2

関連ノート

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