Hydrochloric Acid → HCID 178440201、化合物
反応式
[C:1]([NH:6][C:7]1[CH:15]=[CH:14][C:13]([Cl:16])=[CH:12][C:8]=1[C:9]([NH2:11])=[O:10])(=O)[CH2:2][CH2:3][CH3:4].[OH-].[Na+].Cl>C(O)C>[Cl:16][C:13]1[CH:12]=[C:8]2[C:7](=[CH:15][CH:14]=1)[N:6]=[C:1]([CH2:2][CH2:3][CH3:4])[N:11]=[C:9]2[OH:10]参加物
5
実験手順
2-Butyrylamino-5-chloro-benzamide (1.08 g, 4.49 mmol, 1 eq.), 1.000 N NaOH (13.46 mL, 13.5 mmol, 3 eq.) and ethanol (10 mL) were mixed and stirred at rt for 15 minutes. The mixture was acidified to pH=2 with 1.000 N HCl. The mixture was extracted with ethyl acetate. Solids that did not dissolve were filtered and rinsed with diethyl ether to dry. Obtained 810 mg of a white solid product. LCMS detects (M+H)+=223.
後処理
- extractionThe mixture was extracted with ethyl acetate
- dissolutionSolids that did not dissolve
- filtrationwere filtered
- washrinsed with diethyl ether
- customto dry
出典と根拠
- ORDレコード
- ord-b7f74fa154734f20886fbbdaa684dd15
- 出典データセット
- uspto-grants-2007_02
- 特許番号
- US07183270B2
反応ノート
読み込み中…