Water → HCID 22713205、化合物

HRID 351531ノート

反応式

HRID 351531 の反応式
[H-].[Na+].[C:3]([N:6]1[CH2:11][CH2:10][N:9]([C:12]2[CH:17]=[CH:16][C:15]([OH:18])=[CH:14][CH:13]=2)[CH2:8][CH2:7]1)(=[O:5])[CH3:4].Br[CH:20]1[CH2:25][CH2:24][CH2:23][CH2:22][CH2:21]1.O>CN(C)C=O.C(OCC)(=O)C>[C:3]([N:6]1[CH2:7][CH2:8][N:9]([C:12]2[CH:17]=[CH:16][C:15]([O:18][CH:20]3[CH2:25][CH2:24][CH2:23][CH2:22][CH2:21]3)=[CH:14][CH:13]=2)[CH2:10][CH2:11]1)(=[O:5])[CH3:4]

参加物

7

反応物 4

HCID 962WaterHCID 7960Cyclohexyl bromideHCID 24758Sodium hydrideHCID 7124411-(4-(4-Hydroxyphenyl)piperazin-1-yl)ethanone

生成物 1

HCID 22713205HCID 22713205、化合物

試薬・触媒・溶媒 2

HCID 6228Dimethylformamide溶媒HCID 8857Ethyl Acetate溶媒

反応条件

温度
100 °C

実験手順

To a suspension of sodium hydride (60% suspension in mineral oil) (1.18 g) in dimethylformamide (25 ml) was added 1-acetyl-4-(4-hydroxyphenyl)piperazine (5 g) and bromocyclohexane (5.59 ml) and stirred for 1 hour at 100° C. The reaction mixture was added to a mixture of water and ethyl acetate. The organic layer was taken and dried over magnesium sulfate. The magnesium sulfate was filtered off, and the filtrate was evaporated under reduced pressure to give 1-acetyl-4-(4-cyclohexyloxyphenyl)piperazine (0.92 g).

後処理

  1. dry with materialdried over magnesium sulfate
  2. filtrationThe magnesium sulfate was filtered off
  3. customthe filtrate was evaporated under reduced pressure

出典と根拠

ORDレコード
ord-eb52e27e486347f98cfeb356361f011b
出典データセット
uspto-grants-2004_06
特許番号
US06743776B2

反応ノート

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