Ammonium Hydroxide → (5,6-Dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)Oxoacetamide

HRID 351584ノート

反応式

HRID 351584 の反応式
C[O:2][C:3](=O)[C:4]([C:6]1[C:16]2=[C:17]3[C:12](=[CH:13][CH:14]=[CH:15]2)[CH2:11][CH2:10][CH2:9][N:8]3[CH:7]=1)=[O:5].[OH-].[NH4+:20]>O1CCCC1>[C:6]1([C:4](=[O:5])[C:3]([NH2:20])=[O:2])[C:16]2=[C:17]3[C:12](=[CH:13][CH:14]=[CH:15]2)[CH2:11][CH2:10][CH2:9][N:8]3[CH:7]=1

参加物

4

反応物 2

HCID 14923Ammonium HydroxideHCID 59298805methyl 2-(5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)-2-oxoacetate

生成物 1

HCID 22556693(5,6-Dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)Oxoacetamide収率 86%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

To a solution of (5,6-Dihydro-4H-pyrrolo[3,2,1-ij]quinolin-1-yl)oxoacetic acid methyl ester (0.50 g, 2.06 mmol) in 10 mL of tetrahydrofuran at 0° C. was added concentrated ammonium hydroxide (2 mL). The bath was removed and the mixture stirred 3 hours. After diluting with 20 mL of water, the suspension was filtered, washed with 10 mL of water followed by 10 mL of diethyl ether, and dried under reduced pressure to provide 0.403 g (86%) of the desired compound as a light yellow solid.

後処理

  1. customThe bath was removed
  2. additionAfter diluting with 20 mL of water
  3. filtrationthe suspension was filtered
  4. washwashed with 10 mL of water
  5. customdried under reduced pressure

出典と根拠

ORDレコード
ord-2119dc62522546a589fe04cf02f1a2f1
出典データセット
uspto-grants-2004_06
特許番号
US06743785B2

反応ノート

読み込み中…