Ethyl methanesulfonylacetate → Ethyl 3-dimethylamino-2-methylsulphonylacrylate

HRID 351653

反応式

HRID 351653 の反応式
[CH3:1][S:2]([CH2:5][C:6]([O:8][CH2:9][CH3:10])=[O:7])(=[O:4])=[O:3].CO[CH:13](OC)[N:14]([CH3:16])[CH3:15]>>[CH3:13][N:14]([CH3:16])[CH:15]=[C:5]([S:2]([CH3:1])(=[O:4])=[O:3])[C:6]([O:8][CH2:9][CH3:10])=[O:7]

参加物

3

反応物 2

HCID 78201Ethyl methanesulfonylacetateHCID 78373Dimethylformamide dimethyl acetal

生成物 1

HCID 57126670Ethyl 3-dimethylamino-2-methylsulphonylacrylate

反応条件

温度
85 °C

実験手順

6.65 g (40 mmol) of ethyl methanesulphonylacetate and 5.72 g (48 mmol) of N,N-dimethylformamide dimethyl acetal are admixed and heated at 85° C. overnight. The solution is concentrated using a rotary evaporator, and the solid is comminuted with cyclohexane and filtered off with suction.

後処理

  1. concentrationThe solution is concentrated
  2. customa rotary evaporator
  3. customthe solid is comminuted with cyclohexane
  4. filtrationfiltered off with suction

出典と根拠

ORDレコード
ord-d5b98d3c965f4e9796d425aac5851886
出典データセット
uspto-grants-2004_06
特許番号
US06743798B1

関連ノート

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