Oxalyl chloride → 2-(2-furyl)quinoline-4-carbonyl Chloride

HRID 351723ノート

反応式

HRID 351723 の反応式
[C:1](Cl)(=O)[C:2]([Cl:4])=[O:3].[O:7]1[CH:11]=[CH:10][CH:9]=[C:8]1[C:12]1[CH:21]=C(C(O)=O)[C:19]2[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=2)[N:13]=1>C(Cl)Cl>[O:7]1[CH:11]=[CH:10][CH:9]=[C:8]1[C:12]1[CH:21]=[C:1]([C:2]([Cl:4])=[O:3])[C:19]2[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=2)[N:13]=1

参加物

4

反応物 2

HCID 65578Oxalyl chlorideHCID 6976402-(Furan-2-yl)quinoline-4-carboxylic acid

生成物 1

HCID 106349112-(2-furyl)quinoline-4-carbonyl Chloride収率 100.6%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

反応条件

温度
-10 °C

実験手順

5.2 ml (60.4 mmol) of oxalyl chloride were dissolved in 70 ml of CH2Cl2. The solution was cooled at −10° C. and 8.5 g (35.5 mmol) of 2-(2-furyl)quinoline-4-carboxylic acid were added portionwise. The reaction mixture was left overnight at room temperature and then evaporated to dryness to yield 9.2 g of the title compound, used without further purification.

後処理

  1. customevaporated to dryness

出典と根拠

ORDレコード
ord-462d34639e114df18519164b40748a2f
出典データセット
uspto-grants-2004_06
特許番号
US06743804B2

反応ノート

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