Pyruvic Acid → HCID 53755695、化合物

HRID 35176

反応式

HRID 35176 の反応式
[C:1]([OH:6])(=O)[C:2]([CH3:4])=[O:3].[CH2:7]([O:9][C:10](=[O:16])[C@@H:11]1[CH2:15][CH2:14][CH2:13][NH:12]1)[CH3:8].C1(N=C=NC2CCCCC2)CCCCC1>C(Cl)(Cl)Cl>[CH2:7]([O:9][C:10](=[O:16])[C@@H:11]1[CH2:15][CH2:14][CH2:13][N:12]1[C:1](=[O:6])[C:2]([CH3:4])=[O:3])[CH3:8]

参加物

5

反応物 3

HCID 1060Pyruvic AcidHCID 10868DicyclohexylcarbodiimideHCID 79888L-Proline, ethyl ester

生成物 1

HCID 53755695HCID 53755695、化合物

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒2 回

反応条件

温度
-5 °C

実験手順

A solution of 60 mmoles of pyruvic acid plus 60 mmoles of L-proline ethyl ester in redistilled chloroform is cooled to -50° C. in an acetone-dry ice bath. To this solution is added 60 mmoles of a precooled solution of dicyclohexylcarbodiimide (DCC) in cloroform and the mixture is stirred at -5° C. for 1 hour. The reaction mixture is slowly warmed to room temperature and stirred for an additional 2 hours and then stirred at 4° C. overnight. The mixture is filtered to remove dicyclohexylurea, then cooled in an ice bath. The organic phase is washed with cold water, cold 1N NaHCO3 and finally with cold saturated NaCl. The organic phase is dried over anhydrous MgSO4 and filtered. The solvent is removed with a rotary evaporator yielding N-pyruvoyl-L-proline ethyl ester.

後処理

  1. temperatureThe reaction mixture is slowly warmed to room temperature
  2. stirringstirred for an additional 2 hours
  3. stirringstirred at 4° C. overnight
  4. filtrationThe mixture is filtered
  5. customto remove dicyclohexylurea
  6. temperaturecooled in an ice bath
  7. washThe organic phase is washed with cold water, cold 1N NaHCO3 and finally with cold saturated NaCl
  8. dry with materialThe organic phase is dried over anhydrous MgSO4
  9. filtrationfiltered
  10. customThe solvent is removed with a rotary evaporator

出典と根拠

ORDレコード
ord-8c36c7ea9bdf4d7584a59061c541e8aa
出典データセット
uspto-grants-1988_08
特許番号
US04766110

関連ノート

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