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HRID 351832作成日：2026年10月26日
5-Methylisatoic anhydride → 4-(2,4-Dimethoxy-benzyl)-7-methyl-3,4-dihydro-1H-benzo[e][1,4]diazepine-2,5-dione
https://huagongshe.com/reaction/351832
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 5-Methylisatoic anhydride | HCID 294478 | — |
| 反応物 | (2,4-Dimethoxy-benzylamino)-acetic acid | HCID 11042399 | — |
| 溶媒 | P-Xylene | HCID 7809 | — |
| 生成物 | 4-(2,4-Dimethoxy-benzyl)-7-methyl-3,4-dihydro-1H-benzo[e][1,4]diazepine-2,5-dione | HCID 22713527 | — |
反応手順
A suspension of 6-methyl-2H-3,1-bezoxazine-2,4(1H)-dione (18.3 g, 103 mmol) containing (2,4-dimethoxy-benzylamino)-acetic acid (25.6 g, 114 mmol) in p-xylene (125 mL) was heated under reflux (150° C.) for 2.5 h. After cooling to room temperature the precipitate was filtered off and washed with p-xylene (2×20 ml). Yield: 34.1 g (97%). m/z 341 (MH+).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US06743789B2 |
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| 出典データセット | uspto-grants-2004_06 |
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| ORD ID | ord-7c28ceb6fdba40719215e231b1ea0bf7 |
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| 出典メモ | uspto-grants-2004_06 |
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