O-(Trimethylsilyl)hydroxylamine → HCID 178474861、化合物

HRID 351881

反応式

HRID 351881 の反応式
C[Si](C)(C)[O:3][NH2:4].[C:7]([NH:10][CH2:11][C@@H:12]1[O:16][C:15](=[O:17])[N:14]([C:18]2[CH:23]=[CH:22][C:21]([C:24]#[N:25])=[C:20]([F:26])[CH:19]=2)[CH2:13]1)(=[O:9])[CH3:8]>C(O)C>[C:7]([NH:10][CH2:11][C@@H:12]1[O:16][C:15](=[O:17])[N:14]([C:18]2[CH:23]=[CH:22][C:21]([C:24](=[NH:25])[NH:4][OH:3])=[C:20]([F:26])[CH:19]=2)[CH2:13]1)(=[O:9])[CH3:8]

参加物

4

反応物 2

HCID 2734666O-(Trimethylsilyl)hydroxylamineHCID 229661895-(S)-acetamidomethyl-3-[4'-cyano-3'-fluorophenyl]oxazolidine-2-one

生成物 1

HCID 178474861HCID 178474861、化合物

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

O-Trimethylsilylhydroxylamine (0.37 ml, 3.0 mmol) and 5-(S)-acetamidomethyl-3-[4′-cyano-3′-fluorophenyl]oxazolidine-2-one (0.277 g, 1.0 mmol) in ethanol (3.0 ml) were stirred at 80° C. in a sealed reaction vial for 2.5 h. The mixture was left at r.t. for 48 h, and the crystallized product filtered, rinsed with ethanol (ca. 0.75 ml), washed with ether, and dried under vacuum. Yellow crystals. Yield 0.260 g (84%). HPLC: Rt 2.6 min. MS (m/z): [M+H]+=311.

後処理

  1. filtrationthe crystallized product filtered
  2. washrinsed with ethanol (ca. 0.75 ml)
  3. washwashed with ether
  4. customdried under vacuum

出典と根拠

ORDレコード
ord-340c4767b10a46debfb353ea1607ee36
出典データセット
uspto-grants-2004_06
特許番号
US06743811B2

関連ノート

読み込み中…