Potassium Carbonate → HCID 15549282、化合物

HRID 351926

反応式

HRID 351926 の反応式
[C:1]1([CH:7]([C:14]2[C:22]3[C:17](=[CH:18][C:19]([OH:23])=[CH:20][CH:21]=3)[NH:16][CH:15]=2)[CH2:8][C:9]([O:11][CH2:12][CH3:13])=[O:10])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Br[CH2:25][CH2:26][CH2:27][OH:28].C(=O)([O-])[O-].[K+].[K+]>CC(C)=O>[C:1]1([CH:7]([C:14]2[C:22]3[C:17](=[CH:18][C:19]([O:23][CH2:25][CH2:26][CH2:27][OH:28])=[CH:20][CH:21]=3)[NH:16][CH:15]=2)[CH2:8][C:9]([O:11][CH2:12][CH3:13])=[O:10])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

参加物

5

反応物 3

HCID 11430Potassium CarbonateHCID 123083-Bromo-1-propanolHCID 15549281Ethyl 3-phenyl-3-(6-hydroxyindol-3-yl)propionate

生成物 1

HCID 15549282HCID 15549282、化合物

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

1.2 g (3.88 mmol) of 4 are refluxed overnight in 30 ml of acetone together with 0.66 ml (7.6 mmol) of 3-bromo-1-propanol and 2.1 g (15.2 mmol) of potassium carbonate. After cooling, the insoluble residue is filtered off, and the filtrate is evaporated. The crude product can be purified by chromatography on silica gel (eluent gradient toluene/acetone 9:1→4:1), giving ethyl 3-phenyl-3-[6-(3-hydroxypropoxy)indol-3-yl]propionate.

後処理

  1. temperatureAfter cooling
  2. filtrationthe insoluble residue is filtered off
  3. customthe filtrate is evaporated
  4. customThe crude product can be purified by chromatography on silica gel (eluent gradient toluene/acetone 9:1→4:1)

出典と根拠

ORDレコード
ord-65df8d02bc2e4336aa6a4165735b371b
出典データセット
uspto-grants-2004_06
特許番号
US06743810B2

関連ノート

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