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Potassium Carbonate → Ethyl 3-phenyl-3-[6-(3-hydroxypropoxy)indol-3-yl]propionate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 3-Bromo-1-propanol | HCID 12308 | — |
| 反応物 | Ethyl 3-phenyl-3-(6-hydroxyindol-3-yl)propionate | HCID 15549281 | — |
| 溶媒 | Acetone | HCID 180 | — |
| 生成物 | Ethyl 3-phenyl-3-[6-(3-hydroxypropoxy)indol-3-yl]propionate | HCID 15549282 | — |
反応手順
1.2 g (3.88 mmol) of 4 are refluxed overnight in 30 ml of acetone together with 0.66 ml (7.6 mmol) of 3-bromo-1-propanol and 2.1 g (15.2 mmol) of potassium carbonate. After cooling, the insoluble residue is filtered off, and the filtrate is evaporated. The crude product can be purified by chromatography on silica gel (eluent gradient toluene/acetone 9:1→4:1), giving ethyl 3-phenyl-3-[6-(3-hydroxypropoxy)indol-3-yl]propionate.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06743810B2 |
| 出典データセット | uspto-grants-2004_06 |
| ORD ID | ord-65df8d02bc2e4336aa6a4165735b371b |
| 出典メモ | uspto-grants-2004_06 |