反应详情

1.2 g (3.88 mmol) of 4 are refluxed overnight in 30 ml of acetone together with 0.66 ml (7.6 mmol) of 3-bromo-1-propanol and 2.1 g (15.2 mmol) of potassium carbonate. After cooling, the insoluble residue is filtered off, and the filtrate is evaporated. The crude product can be purified by chromatography on silica gel (eluent gradient toluene/acetone 9:1→4:1), giving ethyl 3-phenyl-3-[6-(3-hydroxypropoxy)indol-3-yl]propionate.

1. temperatureAfter cooling
2. filtrationthe insoluble residue is filtered off
3. customthe filtrate is evaporated
4. customThe crude product can be purified by chromatography on silica gel (eluent gradient toluene/acetone 9:1→4:1)