Sodium Iodide → 4-Chloro-2-[[(1r)-4-iodo-1-phenylbutyl]oxy]benzonitrile

HRID 352104ノート

反応式

HRID 352104 の反応式
[Cl:1][C:2]1[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[C:4]([O:10][C@@H:11]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[CH2:12][CH2:13][CH2:14]Cl)[CH:3]=1.[I-:22].[Na+]>CC(C)=O>[Cl:1][C:2]1[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[C:4]([O:10][C@@H:11]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[CH2:12][CH2:13][CH2:14][I:22])[CH:3]=1

参加物

4

反応物 2

HCID 5238Sodium IodideHCID 698293454-Chloro-2-[[(1r)-4-chloro-1-phenylbutyl]oxy]benzonitrile

生成物 1

HCID 698282664-Chloro-2-[[(1r)-4-iodo-1-phenylbutyl]oxy]benzonitrile収率 89.5%

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

A solution of the product from step (b) (2.80 g) and sodium iodide (20 g) in acetone (100 ml) was heated under reflux for 20 h. The mixture was filtered, evaporated, dissolved in water (50 ml) and extracted with ethyl acetate (three times). The organic extracts were washed with water, dried (magnesium sulphate) and evaporated to give the title compound (3.22 g).

後処理

  1. temperatureunder reflux for 20 h
  2. filtrationThe mixture was filtered
  3. customevaporated
  4. dissolutiondissolved in water (50 ml)
  5. extractionextracted with ethyl acetate (three times)
  6. washThe organic extracts were washed with water
  7. dry with materialdried (magnesium sulphate)
  8. customevaporated

出典と根拠

ORDレコード
ord-7a27ffd422234668b1774412e87fb8de
出典データセット
uspto-grants-2004_06
特許番号
US06743939B2

反応ノート

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