Sodium Iodide → 2-[1-(2,5-Dichlorophenoxy)-4-iodobutyl]thiophene

HRID 352110ノート

反応式

HRID 352110 の反応式
Cl[CH2:2][CH2:3][CH2:4][CH:5]([C:15]1[S:16][CH:17]=[CH:18][CH:19]=1)[O:6][C:7]1[CH:12]=[C:11]([Cl:13])[CH:10]=[CH:9][C:8]=1[Cl:14].[I-:20].[Na+]>CC(C)=O>[Cl:14][C:8]1[CH:9]=[CH:10][C:11]([Cl:13])=[CH:12][C:7]=1[O:6][CH:5]([C:15]1[S:16][CH:17]=[CH:18][CH:19]=1)[CH2:4][CH2:3][CH2:2][I:20]

参加物

4

反応物 2

HCID 5238Sodium IodideHCID 227151352-[4-Chloro-1-(2,5-dichlorophenoxy)butyl]thiophene

生成物 1

HCID 227151002-[1-(2,5-Dichlorophenoxy)-4-iodobutyl]thiophene収率 95%

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

2-[4-Chloro-1-(2,5-dichlorophenoxy)butyl]thiophene (2.4 g, 7.1 mmol) was dissolved in a saturated solution of sodium iodide in acetone (200 ml) and the reaction refluxed for 20 hours. The reaction mixture was cooled and the solid filtered off. The filtrate was evaporated in vacuo and the residue taken up in water (50 ml). The mixture was extracted with diethyl ether (3×70 ml) and the combined organic portions were washed with water (3×30 ml), dried (magnesium sulphate), filtered and evaporated in vacuo to give the title compound as a pale straw coloured oil (2.91 g, 95%).

後処理

  1. temperaturethe reaction refluxed for 20 hours
  2. temperatureThe reaction mixture was cooled
  3. filtrationthe solid filtered off
  4. customThe filtrate was evaporated in vacuo
  5. extractionThe mixture was extracted with diethyl ether (3×70 ml)
  6. washthe combined organic portions were washed with water (3×30 ml)
  7. dry with materialdried (magnesium sulphate)
  8. filtrationfiltered
  9. customevaporated in vacuo

出典と根拠

ORDレコード
ord-69960454100b48cfb073fa3355c7f2ef
出典データセット
uspto-grants-2004_06
特許番号
US06743939B2

反応ノート

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