Hydrochloric Acid → 1-methylpiperidine-3-carboxylic Acid

HRID 352219ノート

反応式

HRID 352219 の反応式
[CH3:1][N:2]1[CH2:12][CH2:11][CH2:10][CH:4]([C:5]([O:7]CC)=[O:6])[CH2:3]1.[OH-].[Li+].Cl>O1CCOCC1.O>[CH3:1][N:2]1[CH2:12][CH2:11][CH2:10][CH:4]([C:5]([OH:7])=[O:6])[CH2:3]1

参加物

6

反応物 3

HCID 313Hydrochloric AcidHCID 3939Lithium HydroxideHCID 97981Ethyl 1-methylpiperidine-3-carboxylate

生成物 1

HCID 27369371-methylpiperidine-3-carboxylic Acid

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 312751,4-Dioxane溶媒

実験手順

To a solution of ethyl 1-methylnipecotate, 0.3 mL (1.65 mmol) in 10 mL of dioxane was added a solution of 118 mg (4.95 mmol) of lithium hydroxide in 10 mL of water. The solution was stirred for 1.5 hours at rt. then was acidified to pH=1 with 5N HCl. The mixture was concentrated to dryness and carried on without further purification. IS (MS) 144.1 (M+1).

後処理

  1. concentrationThe mixture was concentrated to dryness
  2. customcarried on without further purification

出典と根拠

ORDレコード
ord-acb1347dd12c44d5a6e8a22745e1b54a
出典データセット
uspto-grants-2004_06
特許番号
US06743794B2

反応ノート

読み込み中…