反応式
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:9]=[CH:10][CH:11]=1)[CH2:6][CH2:7][NH2:8].C(N(CC)CC)C.[C:19](Cl)(=[O:21])[CH3:20]>C(Cl)(Cl)Cl>[C:19]([NH:8][CH2:7][CH2:6][C:5]1[CH:9]=[CH:10][CH:11]=[C:3]([O:2][CH3:1])[CH:4]=1)(=[O:21])[CH3:20]参加物
5
実験手順
To a stirred solution of 3-methoxyphenethylamine (56.6 g, 0.37 m) and triethylamine (38.0 g, 0.38 m) in CHCl3 (900 ml) was added acetyl chloride (33.0 g, 0.42 m) dropwise over a period of 30 minutes at 20°-25° C., and then the reaction was stirred overnight. The mixture was extracted with 500 ml ice water, then extracted further with 2×500 ml cold water. The chloroform layer was dried over MgSO4 and concentrated to N-acetyl-3-methoxyphenethylamine as an oil (90 g).
後処理
- extractionThe mixture was extracted with 500 ml ice water
- extractionextracted further with 2×500 ml cold water
- dry with materialThe chloroform layer was dried over MgSO4
- concentrationconcentrated to N-acetyl-3-methoxyphenethylamine as an oil (90 g)
出典と根拠
- ORDレコード
- ord-86ad1d2eecbe4aa9925ef2c3f7ffe0b6
- 出典データセット
- uspto-grants-1988_08
- 特許番号
- US04766131
関連ノート
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