Sodium hydride → HCID 22711892、化合物
反応式
[C:1]([C:4]1[CH:9]=[CH:8][C:7]([NH:10][C:11](=[O:13])[CH3:12])=[C:6]([Br:14])[CH:5]=1)(=[O:3])[CH3:2].[H-].[Na+].Br[CH2:18][C:19]([CH3:21])=[CH2:20]>CN(C=O)C>[C:1]([C:4]1[CH:9]=[CH:8][C:7]([N:10]([CH2:20][C:19]([CH3:21])=[CH2:18])[C:11](=[O:13])[CH3:12])=[C:6]([Br:14])[CH:5]=1)(=[O:3])[CH3:2]参加物
5
実験手順
N-(4-Acetyl-2-bromophenyl)acetamide (25 g, 0.1 mole) in dry DMF (250 ml) was treated with sodium hydride (60%, 4.5 g, 0.11 mole) at 25° C. under argon with stirring for 1 h. 3-Bromo-2-methylpropene (1.1 ml, 0.11 mole) was added and the mixture stirred for a further 16 h. The mixture was concentrated in vacuo and partitioned between water and Et2O. The organic phase was dried and concentrated in vacuo to give the title compound (32.8 g, 100%).
後処理
- stirringthe mixture stirred for a further 16 h
- concentrationThe mixture was concentrated in vacuo
- custompartitioned between water and Et2O
- customThe organic phase was dried
- concentrationconcentrated in vacuo
出典と根拠
- ORDレコード
- ord-aaf3b0ffe06442118a5675e293067f49
- 出典データセット
- uspto-grants-2004_06
- 特許番号
- US06747030B1
反応ノート
読み込み中…