1H,3H-furo(3,4-c)pyridine-1,3-dione → N-[4-(heptafluoro-2-propyl)-2-methylphenyl]pyridine-3,4-dicarboximide

HRID 352532

反応式

HRID 352532 の反応式
[N:1]1[CH:6]=[CH:5][C:4]2[C:7]([O:9][C:10](=[O:11])[C:3]=2[CH:2]=1)=O.[F:12][C:13]([C:22]1[CH:28]=[CH:27][C:25]([NH2:26])=[C:24]([CH3:29])[CH:23]=1)([C:18]([F:21])([F:20])[F:19])[C:14]([F:17])([F:16])[F:15]>C1COCC1>[F:12][C:13]([C:22]1[CH:28]=[CH:27][C:25]([N:26]2[C:7](=[O:9])[C:4]3[CH:5]=[CH:6][N:1]=[CH:2][C:3]=3[C:10]2=[O:11])=[C:24]([CH3:29])[CH:23]=1)([C:18]([F:19])([F:20])[F:21])[C:14]([F:17])([F:16])[F:15]

参加物

4

反応物 2

HCID 2783981H,3H-furo(3,4-c)pyridine-1,3-dioneHCID 99255434-(1,1,1,2,3,3,3-Heptafluoropropan-2-yl)-2-methylaniline

生成物 1

HCID 22712038N-[4-(heptafluoro-2-propyl)-2-methylphenyl]pyridine-3,4-dicarboximide

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

In 10 ml of THF were dissolved 1.50 g of pyridine-3,4-dicarboxylic acid anhydride and 2.75 g of 4-(heptafluoro-2-propyl)-2-methylaniline, and the reaction was carried out at room temperature for 3 hours. After completion of the reaction, the solvent was distilled off under reduced pressure and 20 ml of trifluoroacetic anhydride was added to the resulting residue, and the reaction was carried out with refluxing for 3 hours. After completion of the reaction, the solvent was distilled off under reduced pressure to obtain crude N-[4-(heptafluoro-2-propyl)-2-methylphenyl]pyridine-3,4-dicarboximide quantitatively.

後処理

  1. customAfter completion of the reaction
  2. distillationthe solvent was distilled off under reduced pressure and 20 ml of trifluoroacetic anhydride
  3. additionwas added to the resulting residue
  4. temperaturewith refluxing for 3 hours
  5. customAfter completion of the reaction
  6. distillationthe solvent was distilled off under reduced pressure

出典と根拠

ORDレコード
ord-202579acd3bf46baa0df4b8eb4c95e2c
出典データセット
uspto-grants-2004_06
特許番号
US06747041B1

関連ノート

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