beta-Alanylglycine → 3,5-Dichloro-2-fluoro-4-(3-isopropyl-4-hydroxyphenoxy)-6-(3-hydroxycarbonylmethylamino-3-oxopropylamino)pyridine

関与物質

役割	名称	HCID	仕込み量
反応物	beta-Alanylglycine	HCID 137672	—
反応物	3,5-Dichloro-2-fluoro-4-(3-isopropyl-4-methoxyphenoxy)-6-methoxycarbonylmethylamino-pyridine	HCID 9888184	—
生成物	3,5-Dichloro-2-fluoro-4-(3-isopropyl-4-hydroxyphenoxy)-6-(3-hydroxycarbonylmethylamino-3-oxopropylamino)pyridine	HCID 20732329	—

By use of β-alanyl-glycine in place of glycine methyl ester for the preparation of Compound 1e followed by deprotection as described for example 2.