Taurine → 3,5-Dichloro-2-fluoro-4-(3-isopropyl-4-hydroxyphenoxy)-6-(2-hydroxysulfonylethylamino)pyridine

反応式

[NH2:1][CH2:2][CH2:3][S:4]([OH:7])(=[O:6])=[O:5].[Cl:8][C:9]1[C:10]([F:34])=[N:11][C:12](NCC(OC)=O)=[C:13]([Cl:27])[C:14]=1[O:15][C:16]1[CH:21]=[CH:20][C:19]([O:22]C)=[C:18]([CH:24]([CH3:26])[CH3:25])[CH:17]=1>>[Cl:8][C:9]1[C:10]([F:34])=[N:11][C:12]([NH:1][CH2:2][CH2:3][S:4]([OH:7])(=[O:6])=[O:5])=[C:13]([Cl:27])[C:14]=1[O:15][C:16]1[CH:21]=[CH:20][C:19]([OH:22])=[C:18]([CH:24]([CH3:26])[CH3:25])[CH:17]=1

参加物

反応物 2

HCID 1123Taurine

HCID 98881843,5-Dichloro-2-fluoro-4-(3-isopropyl-4-methoxyphenoxy)-6-methoxycarbonylmethylamino-pyridine

生成物 1

HCID 227121133,5-Dichloro-2-fluoro-4-(3-isopropyl-4-hydroxyphenoxy)-6-(2-hydroxysulfonylethylamino)pyridine

実験手順

By use of 2-aminoethylsulfonic acid in place of glycine methyl ester for the preparation of Compound 1e followed by deprotection as described for example 2.

出典と根拠

ORDレコード: ord-0c10dec69a284944882e38c2d9a60f2f
出典データセット: uspto-grants-2004_06
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US06747048B2

反応ノート

読み込み中…