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Hydrochloric Acid → 4-Aminobenzene-1,3-dioic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Lithium hydroxide, monohydrate | HCID 168937 | — |
| 反応物 | 1,3-Benzenedicarboxylic acid, 4-amino-, 1-methyl ester | HCID 22591727 | — |
| 溶媒 | Water | HCID 962 | — |
| 溶媒 | 1,4-Dioxane | HCID 31275 | — |
| 生成物 | 4-Aminobenzene-1,3-dioic acid | HCID 11355852 | 95.7% |
反応手順
6.3 g (150 mmol) of LiOH.H2O are added to a stirred solution of 15.7 g (75 mmol) of methyl 4-amino-isophtalate in 300 ml of dioxane and 1200 ml of water. The reaction mixture is heated for 1 hour to 100° C., cooled and acidified to pH=1 by the addition of concentrated HCl. A precipitate is obtained then filtered off, washed, and dried under vacuum to yield 13 g (yield=95.7%) of the desired compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06747147B2 |
| 出典データセット | uspto-grants-2004_06 |
| ORD ID | ord-78088589acad47cca89cd3e3791a19bc |
| 出典メモ | uspto-grants-2004_06 |