反应详情

6.3 g (150 mmol) of LiOH.H2O are added to a stirred solution of 15.7 g (75 mmol) of methyl 4-amino-isophtalate in 300 ml of dioxane and 1200 ml of water. The reaction mixture is heated for 1 hour to 100° C., cooled and acidified to pH=1 by the addition of concentrated HCl. A precipitate is obtained then filtered off, washed, and dried under vacuum to yield 13 g (yield=95.7%) of the desired compound.

1. temperatureThe reaction mixture is heated for 1 hour to 100° C.
2. temperaturecooled
3. customA precipitate is obtained
4. filtrationthen filtered off
5. washwashed
6. customdried under vacuum