Ethyl 5-hydrazino-3-(pyridin-4-yl)-1,2,4-triazine-6-carboxylate → Ethyl 3-(pyridin-4-yl)-1,2,4-triazin-6-carboxylate
反応式
N([C:3]1[N:4]=[C:5]([C:14]2[CH:19]=[CH:18][N:17]=[CH:16][CH:15]=2)[N:6]=[N:7][C:8]=1[C:9]([O:11][CH2:12][CH3:13])=[O:10])N>C(O)C.[Hg]=O>[N:17]1[CH:18]=[CH:19][C:14]([C:5]2[N:6]=[N:7][C:8]([C:9]([O:11][CH2:12][CH3:13])=[O:10])=[CH:3][N:4]=2)=[CH:15][CH:16]=1参加物
4
実験手順
In ethanol (5 ml) was suspended ethyl 5-hydrazino-3-(pyridin-4-yl)-1,2,4-triazine-6-carboxylate (50 mg). To the resulting suspension, mercury (II) oxide (98 mg) was added and the resulting mixture was heated under reflux for 9 hours. After completion of the reaction, the insoluble matter was removed through Celite filtration. The filtrate was concentrated and the concentrate was separated into layers by the addition of ethyl acetate and water. The organic layer thus obtained was dried over anhydrous magnesium sulfate. The filtrate was concentrated, whereby a crudely purified product of the title compound (23 mg, pale yellow powder) was obtained.