Methanol → methyl 1H-benzimidazole-5-carboxylate hydrochloride

HRID 352842

反応式

HRID 352842 の反応式
S(Cl)([Cl:3])=O.[N:5]1[C:9]2[CH:10]=[CH:11][C:12]([C:14]([OH:16])=[O:15])=[CH:13][C:8]=2[NH:7][CH:6]=1.[CH3:17]O>>[ClH:3].[N:5]1[C:9]2[CH:10]=[CH:11][C:12]([C:14]([O:16][CH3:17])=[O:15])=[CH:13][C:8]=2[NH:7][CH:6]=1

参加物

4

反応物 3

HCID 887MethanolHCID 24386Thionyl ChlorideHCID 4594565-Benzimidazolecarboxylic acid

生成物 1

HCID 22710297methyl 1H-benzimidazole-5-carboxylate hydrochloride収率 97%

実験手順

Under ice cooling, thionyl chloride (2.30 ml) was added dropwise to methanol (50 ml). Then, 5-benzimidazolecarboxylic acid (5.00 g) was added, followed by heating under reflux for 5 hours. The reaction mixture was distilled under reduced pressure. The residue was pulverized in diethyl ether, followed by collection through filtration, whereby colorless crystals (6.36 g, 97%) was obtained.

後処理

  1. temperatureby heating
  2. temperatureunder reflux for 5 hours
  3. distillationThe reaction mixture was distilled under reduced pressure
  4. filtrationfollowed by collection through filtration

出典と根拠

ORDレコード
ord-f89a7e124718480098b5995cbd3b23e9
出典データセット
uspto-grants-2004_06
特許番号
US06747023B1

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