Trifluoroacetic acid → HCID 69881589、化合物

HRID 352974ノート

反応式

HRID 352974 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[CH:8]=[C:7]([S:12]([N:15]1[CH2:20][CH2:19][N:18]([C:21]([C:23]3[S:24][C:25]4[CH2:26][NH:27][CH:28]([CH2:32][C:33]([O:35]C(C)(C)C)=[O:34])[CH2:29][C:30]=4[N:31]=3)=[O:22])[CH2:17][CH2:16]1)(=[O:14])=[O:13])[CH:6]=[CH:5]2.[F:40][C:41]([F:46])([F:45])[C:42]([OH:44])=[O:43]>C(Cl)Cl>[F:40][C:41]([F:46])([F:45])[C:42]([OH:44])=[O:43].[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[CH:8]=[C:7]([S:12]([N:15]1[CH2:20][CH2:19][N:18]([C:21]([C:23]3[S:24][C:25]4[CH2:26][NH:27][CH:28]([CH2:32][C:33]([OH:35])=[O:34])[CH2:29][C:30]=4[N:31]=3)=[O:22])[CH2:17][CH2:16]1)(=[O:14])=[O:13])[CH:6]=[CH:5]2

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 86592091HCID 86592091、化合物

生成物 1

HCID 69881589HCID 69881589、化合物

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

In methylene chloride (1 ml) was dissolved tert-butyl [2-[[4-[(6-chloronaphthalen-2-yl)sulfonyl]piperazin-1-yl]carbonyl]-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-6-yl)acetate (200 mg), followed by the addition of trifluoroacetic acid (2 ml). The resulting mixture was stirred at room temperature for 2 hours. After concentration under reduced pressure, diethyl ether was added to the residue. The precipitate so formed was collected by filtration, whereby the title compound (193 mg) was obtained as a colorless foam.

後処理

  1. concentrationAfter concentration under reduced pressure, diethyl ether
  2. additionwas added to the residue
  3. customThe precipitate so formed
  4. filtrationwas collected by filtration, whereby the title compound (193 mg)
  5. customwas obtained as a colorless foam

出典と根拠

ORDレコード
ord-54e2a7f17c414988a04fec6518102959
出典データセット
uspto-grants-2004_06
特許番号
US06747023B1

反応ノート

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