Nitric Acid → 6-Nitrobenzothiazole

HRID 353018

反応式

HRID 353018 の反応式
C[C:2]1[S:3][C:4]2[CH:10]=[CH:9][CH:8]=[CH:7][C:5]=2[N:6]=1.[N+:11]([O-])([OH:13])=[O:12]>S(=O)(=O)(O)O>[N+:11]([C:9]1[CH:8]=[CH:7][C:5]2[N:6]=[CH:2][S:3][C:4]=2[CH:10]=1)([O-:13])=[O:12]

参加物

4

反応物 2

HCID 944Nitric AcidHCID 84462-Methylbenzothiazole2 回

生成物 1

HCID 762566-Nitrobenzothiazole

試薬・触媒・溶媒 1

HCID 1118Sulfuric Acid溶媒2 回

実験手順

See FIG. 3A. Nitration of 2-methylbenzothiazole was performed following the method of Mizuno, J. Pharm. Soc. Japan, 72, 745 (1952). A mixture of fuming nitric acid (1.6 mL) and concentrated sulfuric acid (1.2 mL) was added to an ice-cooled solution of 2-methylbenzothiazole (2 g) in sulfuric acid (8 mL). The solution was allowed to warm to room temperature for one hour, then poured onto 100 mL of ice. The solid was filtered, washed with water, and recrystallized from ethanol (80 mL) to provide 2.5 g of yellowish needles.

後処理

  1. filtrationThe solid was filtered
  2. washwashed with water
  3. customrecrystallized from ethanol (80 mL)

出典と根拠

ORDレコード
ord-2ed0bbd2a51e40069fca902b09766555
出典データセット
uspto-grants-2004_06
特許番号
US06750024B2

関連ノート

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