Cyanoacetamide → HCID 22707993、化合物

HRID 353222ノート

反応式

HRID 353222 の反応式
[Na].[O:2]1[CH:6]=[CH:5][CH:4]=[C:3]1[C:7](=O)/[CH:8]=[C:9](/[O:12][CH:13]([CH3:15])[CH3:14])\SC.[C:17]([CH2:19][C:20]([NH2:22])=[O:21])#[N:18]>C(O)(C)C>[O:2]1[CH:6]=[CH:5][CH:4]=[C:3]1[C:7]1[NH:22][C:20](=[O:21])[C:19]([C:17]#[N:18])=[C:9]([O:12][CH:13]([CH3:15])[CH3:14])[CH:8]=1

参加物

5

反応物 3

HCID 7898CyanoacetamideHCID 5360545SodiumHCID 60091526HCID 60091526、化合物

生成物 1

HCID 22707993HCID 22707993、化合物収率 70.3%

試薬・触媒・溶媒 1

HCID 3776Isopropanol溶媒

実験手順

Sodium (309 mg, 13.4 mmol) was dissolved in isopropanol (46 mL). Then, (Z)-1-(2-furyl)-3-isopropoxy-3-(methylsulfanyl)-2-propen-1-one (3.03 g, 13.4 mmol) and 2-cyanoacetamide (1.13 g, 13.4 mmol) were added thereto, followed by stirring overnight at room temperature. Ice-water was added to the reaction solution, and then the solid was collected by filtration, and washed with water and diethyl ether, to give the title compound (2.3 g, 70%).

後処理

  1. filtrationthe solid was collected by filtration
  2. washwashed with water and diethyl ether

出典と根拠

ORDレコード
ord-69eaa9961faa4a79a7500d69d4374a09
出典データセット
uspto-grants-2004_06
特許番号
US06750232B2

反応ノート

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