Hydrochloric Acid → 2-Amino-5-(1-ethyl-6-oxo-1,6-dihydro-3-pyridinyl)-6-(2-furyl)nicotinic acid

反応式

[OH-:1].[Na+].[NH2:3][C:4]1[N:11]=[C:10]([C:12]2[O:13][CH:14]=[CH:15][CH:16]=2)[C:9]([C:17]2[CH:22]=[CH:21][C:20](=[O:23])[N:19]([CH2:24][CH3:25])[CH:18]=2)=[CH:8]C=1C#N.Cl.[CH2:27]([OH:29])[CH3:28]>>[NH2:3][C:4]1[N:11]=[C:10]([C:12]2[O:13][CH:14]=[CH:15][CH:16]=2)[C:9]([C:17]2[CH:22]=[CH:21][C:20](=[O:23])[N:19]([CH2:24][CH3:25])[CH:18]=2)=[CH:8][C:28]=1[C:27]([OH:1])=[O:29]

参加物

反応物 4

HCID 313Hydrochloric Acid

HCID 702Ethanol

HCID 14798Sodium Hydroxide

HCID 129921352-Amino-5-(1-ethyl-6-oxo-1,6-dihydro-3-pyridinyl)-6-(2-furyl)nicotinonitrile

生成物 1

HCID 129921372-Amino-5-(1-ethyl-6-oxo-1,6-dihydro-3-pyridinyl)-6-(2-furyl)nicotinic acid収率 98%

実験手順

Ethanol (5 mL) and 5 N aqueous sodium hydroxide (10 mL) were added to 2-amino-5-(1-ethyl-6-oxo-1,6-dihydro-3-pyridinyl)-6-(2-furyl)nicotinonitrile (308 mg, 1.01 mmol), followed by heating under reflux for 4 hours. After cooling as it was, the reaction solution was neutralized with 5 N hydrochloric acid. The resulting solid was collected by filtration and then washed with water, to give the title compound (320 mg, 98%) as a yellow solid.