1-Acetyl-4-(4-nitrophenyl)piperazine → 1-[4-(4-Aminophenyl)piperazin-1-yl]ethan-1-one

HRID 353718

反応式

HRID 353718 の反応式
[C:1]([N:4]1[CH2:9][CH2:8][N:7]([C:10]2[CH:15]=[CH:14][C:13]([N+:16]([O-])=O)=[CH:12][CH:11]=2)[CH2:6][CH2:5]1)(=[O:3])[CH3:2]>C(O)C.[Pd]>[C:1]([N:4]1[CH2:5][CH2:6][N:7]([C:10]2[CH:15]=[CH:14][C:13]([NH2:16])=[CH:12][CH:11]=2)[CH2:8][CH2:9]1)(=[O:3])[CH3:2]

参加物

4

反応物 1

HCID 28651491-Acetyl-4-(4-nitrophenyl)piperazine

生成物 1

HCID 7362691-[4-(4-Aminophenyl)piperazin-1-yl]ethan-1-one収率 63.3%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

A mixture of 1-acetyl-4-(4-nitrophenyl)piperazine (1.8 g, 7.2 mmol) (from Step A above) and 10% palladium-on-charcoal in ethanol (50 mL) was hydrogenated at room temperature and atmospheric pressure overnight. The catalyst was filtered off and the filter cake washed thoroughly with ethanol. The mixture was evaporated under reduced pressure to give 1-acetyl-4-(4-amino-phenyl)piperazine (1.0 g, 63%) as an off-white solid.

後処理

  1. customwas hydrogenated at room temperature
  2. customatmospheric pressure overnight
  3. filtrationThe catalyst was filtered off
  4. washthe filter cake washed thoroughly with ethanol
  5. customThe mixture was evaporated under reduced pressure

出典と根拠

ORDレコード
ord-143dbfbc16664caf8759b3054bd49f39
出典データセット
uspto-grants-2004_06
特許番号
US06756374B2

関連ノート

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