Chlorosulfonic acid → 3-Methoxy-5,6,7,8-tetrahydronaphthalene-2-sulfonyl chloride

HRID 35399

反応式

HRID 35399 の反応式
[CH3:1][O:2][C:3]1[CH:12]=[CH:11][C:10]2[CH2:9][CH2:8][CH2:7][CH2:6][C:5]=2[CH:4]=1.[Cl:13][S:14](O)(=[O:16])=[O:15]>C(Cl)Cl>[CH3:1][O:2][C:3]1[C:12]([S:14]([Cl:13])(=[O:16])=[O:15])=[CH:11][C:10]2[CH2:9][CH2:8][CH2:7][CH2:6][C:5]=2[CH:4]=1

参加物

4

反応物 2

HCID 24638Chlorosulfonic acidHCID 744146-Methoxytetralin

生成物 1

HCID 132103423-Methoxy-5,6,7,8-tetrahydronaphthalene-2-sulfonyl chloride

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒2 回

反応条件

温度
5 °C

実験手順

118 g (0.73 mole) of 5,6,7,8-tetrahydro-2-naphthol methyl ether are dissolved in 320 ml of methylene chloride, and 177 ml of chlorosulfonic acid in 160 ml of methylene chloride are added. The mixture is stirred for 10 minutes at 5° C. and is poured into ice water. The organic phase is separated off and dried with MgSO4. The solvent is removed by evaporation and the residue is recrystallized from acetone/petroleum ether.

後処理

  1. customThe organic phase is separated off
  2. dry with materialdried with MgSO4
  3. customThe solvent is removed by evaporation
  4. customthe residue is recrystallized from acetone/petroleum ether

出典と根拠

ORDレコード
ord-7aed8e15419c45bdbbd0df5886e4abad
出典データセット
uspto-grants-1988_08
特許番号
US04766241

関連ノート

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