Diisobutylaluminum hydride → (4-Hydroxymethylthiazol-2-yl)carbamic acid tert-butyl ester
反応式
[C:1]([NH:8][C:9]1[S:10][CH:11]=[C:12]([C:14](OCC)=[O:15])[N:13]=1)([O:3][C:4]([CH3:7])([CH3:6])[CH3:5])=[O:2].CC(C[AlH]CC(C)C)C>C(Cl)Cl>[C:1]([NH:8][C:9]1[S:10][CH:11]=[C:12]([CH2:14][OH:15])[N:13]=1)([O:3][C:4]([CH3:7])([CH3:6])[CH3:5])=[O:2]参加物
4
反応条件
- 温度
- -60 °C
実験手順
A solution of ethyl 2-[(N-Boc)amino]-4-thiazolecarboxylate (1 mmole) in CH2Cl2 (10 mL) was cooled to −78° C., and treated with DIBAL-H (1M, 5 ML). The reaction was stirred at −60° C. for 3 h, and quenched with a suspension of NaF/H2O (1 g/1 mL). The resulting mixture was filtered and the filtrate was concentrated to give 2-[(N-Boc)amino]-4-hydroxymethylthiazole as a solid.
後処理
- customquenched with a suspension of NaF/H2O (1 g/1 mL)
- filtrationThe resulting mixture was filtered
- concentrationthe filtrate was concentrated
出典と根拠
- ORDレコード
- ord-e54be4ccf6624a928e5630811ab220bd
- 出典データセット
- uspto-grants-2004_06
- 特許番号
- US06756360B1
反応ノート
読み込み中…